Accelerating to better health

Rivus Pharmaceuticals is dedicated to improving cardio-metabolic health by developing controlled metabolic accelerators (CMAs) that address the underlying metabolic risk factors for cardiovascular mortality and morbidity.

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Rivus Pharmaceuticals is dedicated to improving cardio-metabolic health by developing controlled metabolic accelerators (CMAs) that address the underlying metabolic risk factors for cardiovascular mortality and morbidity.

OUR SCIENCE

Rivus’ Controlled Metabolic Accelerators (CMAs) Harness the Body’s Natural Processes to Improve Metabolism

Rivus is advancing a new therapeutic approach that harnesses the body’s natural metabolic processes to improve cellular metabolism and reverse the course of disease. Metabolic disorders are a primary driver of cardiovascular disease and mortality and include conditions such as hypertension, type 2 diabetes, dyslipidemia, obesity, non-alcoholic steatohepatitis (NASH), and others. Current treatments address the downstream effects of poor metabolic health but do little to address the underlying causes.

LEARN MORE ABOUT CMAs
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Rivus’ controlled metabolic accelerators (CMAs) are oral, small-molecule therapies designed to effectively address the root cause of metabolic disease, the accumulation of fat and sugars in the body.

CMAs work to improve cellular metabolism and increase energy expenditure and calorie consumption, reducing the accumulation of substrate fat. Approximately 20-40% of calories are consumed by the natural process of mitochondrial uncoupling, a significant contributor to basal metabolic rate. CMAs increase this natural process to restore energy balance.

Rivus’ controlled metabolic accelerators (CMAs) are oral, small-molecule therapies designed to effectively address the root cause of metabolic disease, the accumulation of fat and sugars in the body.

CMAs work to improve cellular metabolism and increase energy expenditure and calorie consumption, reducing the accumulation of substrate fat. Approximately 20-40% of calories are consumed by the natural process of mitochondrial uncoupling, a significant contributor to basal metabolic rate. CMAs increase this natural process to restore energy balance.

OUR PIPELINE

CMAs have the potential to provide well-tolerated, effective treatments that improve cardio-metabolic health with applicability to a broad range of disease targets.

For its lead program HU6, Rivus Pharmaceuticals has completed Phase 1 clinical studies and is currently conducting a Phase 2a metabolic study that will support multiple Phase 2b studies in metabolic disease including type 2 diabetes, severe hypertriglyceridemia (SHTG), and non-alcoholic steatohepatitis (NASH). Rivus is also initiating a Phase 2a study in heart failure with preserved ejection fraction (HFpEF).

LEARN MORE ABOUT OUR PIPELINE

HU6 DEVELOPMENT PIPELINE

Indication
Phase I
Phase II
Phase III
T2D
NASH
SHTG
HFpEF
Indication
T2D
Phase II
Indication
NASH
Phase II
Indication
SHTG
Phase II
Indication
HFpEF
Phase I

Our Team

The Rivus team is a group of forward-thinking scientists and proven biotech leaders deeply committed to the field of metabolic health. Our team of experts is driven to provide patients and physicians with a new and highly effective solution to one of the most challenging issues in healthcare today.

Allen Cunningham
Allen Cunningham
Chief Executive Officer
Allen Cunningham
Allen Cunningham
Chief Executive Officer

Allen Cunningham is the Chief Executive Officer at Rivus. He brings more than twenty years of experience developing early-stage and venture-backed companies across a number of sectors, including biotechnology, information technology, and renewable energy. Allen has expertise in all aspects of early-stage company development, including operations management, intellectual property, product development, licensing and distribution, mergers and acquisition, and finance. Prior to Rivus, he co-founded and served as the CEO of Gencia Biotech. Allen graduated from the University of Virginia with a Bachelor of Arts in English.

Shaharyar Khan
Shaharyar Khan, Ph.D.
Chief Scientific Officer
Shaharyar Khan
Shaharyar Khan, Ph.D.
Chief Scientific Officer

Shaharyar Khan is Chief Scientific Officer at Rivus. An expert in mitochondrial biology and seasoned leader with more than two decades of experience managing multidisciplinary teams of talented mitochondrial biologists, computational and medicinal chemists, and clinicians. Shaharayar is dedicated to the pursuit of novel mitochondrial therapeutics. He co-founded Gencia Biotech where he also served as CSO. At Gencia, Shaharyar pioneered multiple drug discovery programs, including large and small molecules, aimed at harnessing the unique role of mitochondria in the maintenance of cellular health. Shaharyar earned his PhD in Neuroscience from the University of Virginia.

Francisco Portell
Francisco Portell
VP, Pharmaceutical Development
Francisco Portell
Francisco Portell
VP, Pharmaceutical Development

Francisco Portell is the VP, Pharmaceutical Development at Rivus. With over 20 years of research experience in mitochondrial biology, Francisco has worked on multiple drug discovery programs involving both large and small molecules. As a co-founder of and Senior Scientist at Gencia, he led the biologics development program and partnering efforts with industry experts on bacterial genetics, fermentation, tangential flow filtration, chromatography and formulation. Prior to Gencia, Francisco worked at the University of Virginia Center for Neurodegeneration researching mitochondrial dysfunction in Alzheimer’s and Parkinson’s disease.

Jayson Dallas
Jayson Dallas
Executive Chair
Jayson Dallas
Jayson Dallas
Executive Chair

Jayson Dallas has served on the Board of Directors at Arena Pharmaceuticals since February 2017. Dr. Dallas has served as President and Chief Executive Officer of Aimmune Therapeutics, Inc., a biopharmaceutical company developing treatments for potentially life-threatening food allergies, since June 2018 Prior to joining Aimmune, he served as the first Chief Commercial Officer and Executive Vice President of Ultragenyx Pharmaceutical, Inc., a publicly held biopharmaceutical company focused on the development of novel products for rare and ultra-rare diseases, since August 2015. Prior to Ultragenyx, Dr. Dallas served as General Manager of Roche, a healthcare company, in the United Kingdom from January 2013 to July 2015. Before joining Roche, he held two different positions at Genentech, a pharmaceutical company, as Head of Global Oncology Launch Excellence and Biosimilar Strategy and Head of Global Product Strategy for Immunology and Ophthalmology, from May 2010 to December 2012 in South San Francisco. Earlier in his career, Dr. Dallas worked at Novartis and Pfizer / Pharmacia in the United States and previously at Roche in Switzerland. Dr. Dallas holds an M.D. from the University of the Witwatersrand, Johannesburg, South Africa and an M.B.A. from Ashridge Business School in the United Kingdom.

Patrick Enright
Patrick Enright
Patrick Enright
Patrick Enright

Patrick Enright is a Managing Director and Founder of Longitude Capital. Prior to Longitude Capital, Mr. Enright was a Managing Director of Pequot Ventures where he co-led the life sciences investment practice. Prior to Pequot, he was a Managing Member of the Delta Opportunity Fund at Diaz & Altschul Capital Management. Mr. Enright began his investment career at PaineWebber Development Corporation. Mr. Enright also has significant life sciences operations experience, including senior executive positions at Valentis (VLTS), Boehringer Mannheim (acquired by Roche) and Sandoz (now known as Novartis). Mr. Enright currently serves on the boards of Aptinyx (APTX), CuraSen Therapeutics, Dascena, Epirium Bio, Jazz Pharmaceuticals (JAZZ), Orbus Therapeutics, Vera Therapeutics (VERA) as well as the National Venture Capital Association (NVCA). Selected prior board memberships include Aimmune (AIMT, acquired by Nestlé Health Science), Codexis (CDXS), Corcept Therapeutics (CORT), Esperion Therapeutics (ESPR), Horizon Pharmaceuticals (HZNP), InfaCare Pharmaceutical, MAP Pharmaceuticals (MAPP, acquired by Allergan), Prestwick Pharmaceuticals (acquired by Lundbeck), Sequenom (SQNM, acquired by LabCorp), Threshold Pharmaceuticals (THLD, acquired by Molecular Templates) and Vaxcyte (PCVX). Mr. Enright holds an M.B.A. from the Wharton School of Business at the University of Pennsylvania and a B.S. in Biological Sciences from Stanford University.

Francesco De Rubertis
Francesco De Rubertis
Francesco De Rubertis
Francesco De Rubertis

Francesco De Rubertis is a co-founder and Partner at Medicxi since 2016. Prior to Medicxi, Francesco was a Partner at Index Ventures for 19 years, having joined the firm in 1997 to launch its life sciences practice. Dr. De Rubertis serves on the boards of a number of private biotechnology companies, including Rivus Pharmaceuticals, Synox Therapeutics and Levicept. Dr. De Rubertis’s prior investments include CellZome, GenMab (Copenhagen: GEN.CO), GenSight Biologics (Euronext: SIGHT), Micromet, Minerva Neurosciences (NASDAQ:NERV), Molecular Partners (Swiss:MOLN.SW), PanGenetics, Parallele Biosciences, Profibrix and Versartis (NASDAQ:VSAR). Dr. De Rubertis received a B.A. in Genetics and Microbiology from the University of Pavia (Italy) and a PhD in Molecular Biology from the University of Geneva (Switzerland) after which he became a postdoctoral scientist at the Whitehead Institute at M.I.T. He is a Chartered Financial Analyst and serves on the main board of the University of Geneva (Switzerland).

Allen Cunningham
Allen Cunningham
Chief Executive Officer
Allen Cunningham
Allen Cunningham
Chief Executive Officer

Allen Cunningham is the Chief Executive Officer at Rivus. He brings more than twenty years of experience developing early-stage and venture-backed companies across a number of sectors, including biotechnology, information technology, and renewable energy. Allen has expertise in all aspects of early-stage company development, including operations management, intellectual property, product development, licensing and distribution, mergers and acquisition, and finance. Prior to Rivus, he co-founded and served as the CEO of Gencia Biotech. Allen graduated from the University of Virginia with a Bachelor of Arts in English.

Shaharyar Khan
Shaharyar Khan, Ph.D.
Chief Scientific Officer
Shaharyar Khan
Shaharyar Khan, Ph.D.
Chief Scientific Officer

Shaharyar Khan is Chief Scientific Officer at Rivus. An expert in mitochondrial biology and seasoned leader with more than two decades of experience managing multidisciplinary teams of talented mitochondrial biologists, computational and medicinal chemists, and clinicians. Shaharayar is dedicated to the pursuit of novel mitochondrial therapeutics. He co-founded Gencia Biotech where he also served as CSO. At Gencia, Shaharyar pioneered multiple drug discovery programs, including large and small molecules, aimed at harnessing the unique role of mitochondria in the maintenance of cellular health. Shaharyar earned his PhD in Neuroscience from the University of Virginia.

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CAREERS

Rivus is headquartered in Charlottesville, Virginia and is seeking candidates to join our growing team as we continue to develop our controlled metabolic accelerator (CMA) technology.

NEWS

Learn more about Rivus and controlled metabolic accelerators (CMAs).

PRESS RELEASES

Rivus Pharmaceuticals Launches with $35 Million Series A Financing to Develop Novel Treatments for Cardio-Metabolic Diseases

NEWS

PRESS RELEASES

Rivus Pharmaceuticals Launches with $35 Million Series A Financing to Develop Novel Treatments for Cardio-Metabolic Diseases

Advancing a pipeline of first-in-class Controlled Metabolic Accelerators (CMAs) to harness the body’s natural processes to improve cellular metabolism and treat the underlying causes of poor metabolic health and cardiovascular disease

Initial programs to focus on type 2 diabetes, severe hypertriglyceridemia (SHTG), non-alcoholic steatohepatitis (NASH), heart failure with preserved ejection fraction (HFpEF)

CHARLOTTESVILLE, Va., July 20, 2021 /PRNewswire/ — Rivus Pharmaceuticals, Inc., a biopharmaceutical company dedicated to improving cardio-metabolic health, today announced the completion of a $35 million Series A financing. Rivus is advancing a new class of oral, once daily, small molecule therapeutics called Controlled Metabolic Accelerators (CMAs), designed to improve cellular metabolism and treat the underlying cause of highly-prevalent metabolic and cardiovascular diseases. The round was co-led by Longitude Capital and Medicxi and RxCapital also participated.

“More than 40 million people in the U.S. alone are living with cardio-metabolic disorders, conditions that adversely impact a person’s health and quality of life, as well as place significant cost burdens on healthcare systems. While many existing therapeutic options address the downstream effects of metabolic disease, they do little to address the underlying cause – greater consumption of energy than is required by the body, which over time results in inefficient cellular metabolism and the excess accumulation of fat,” said Allen Cunningham, President and CEO, Rivus Pharmaceuticals. “Our CMAs are designed to effectively target the root cause of these diseases by improving cellular metabolism with the potential to halt the progress of, or even reverse, these diseases.”

CMAs provide a new, measured approach to activating mitochondrial uncoupling, a natural process in the body that regulates and dissipates energy. By ferrying protons out of the mitochondrial intermembrane space, CMAs cue the increased oxidation of sugars and fats, while maintaining the same baseline production of adenosine triphosphate (ATP).  Activating this process results in the reduction of accumulated fat and the prevention of additional fat accumulation throughout the body. Rivus is currently conducting a Phase 2a clinical study with its lead CMA therapeutic, HU6. The Series A financing will enable Rivus to advance a pipeline of CMA therapies to treat a range of metabolic conditions including type 2 diabetes, severe hypertriglyceridemia (SHTG), non-alcoholic steatohepatitis (NASH), as well as cardiovascular diseases such as heart failure with preserved ejection fraction (HFpEF).

“We are very encouraged by early clinical results of HU6 and the potential for CMAs to deliver a new and highly-effective approach to improving metabolic health,” said Patrick Enright, Managing Director at Longitude Capital. “There is tremendous global potential for CMAs to fundamentally change the therapeutic landscape across a variety of difficult to manage chronic diseases related to metabolic health.”

“Rivus has recently completed its Phase 1 program for HU6, and the results exceeded our expectations, demonstrating an early positive impact on key metabolic parameters, while being well-tolerated,” said David Grainger, Ph.D., Chief Scientific Advisor at Medicxi. “Phase 2 studies will provide important insights into HU6’s efficacy in specific metabolic and cardiovascular diseases with this very promising new therapy, and we are excited to advance these programs in partnership with Rivus.”

# # #

About Rivus Pharmaceuticals

Rivus Pharmaceuticals, Inc., is dedicated to transforming the treatment of cardio-metabolic disease. Rivus’ first-in-class, small molecule therapy, HU6, is a controlled metabolic accelerator (CMA) that addresses the underlying cause of cardio-metabolic disease by harnessing the body’s natural processes to improve cellular metabolism. Rivus’ therapy presents a tremendous opportunity to empower patients on their journey to better health when facing a broad range of cardio-metabolic conditions, including type 2 diabetes, hypertension, non-alcoholic steatohepatitis (NASH), dyslipidemia and obesity. For more information, please visit www.rivuspharma.com.

About Longitude Capital

Longitude Capital is a leading healthcare venture capital firm that invests in transformative biotechnology, medical technology and health solutions companies seeking to improve clinical outcomes, enhance quality of life, and drive efficiency of healthcare delivery. Founded in 2006, Longitude Capital invests in both privately held and publicly traded companies through a variety of investment approaches. Longitude Capital has offices in Menlo Park, CA, Greenwich, CT, and Boston, MA. For more information, please visit www.longitudecapital.com or LinkedIn.

About Medicxi

Medicxi is an international investment firm with the mission to create and invest in companies across the full healthcare continuum. Medicxi was established by the former Index Ventures life sciences team and invests in both early stage and late stage therapeutics with a product vision that can fulfill a clear unmet medical need. GlaxoSmithKline, Johnson & Johnson Innovation – JJDC, Inc., Novartis and Verily (an Alphabet company) are investors in Medicxi funds.

Medicxi’s team has been investing in life sciences for over 20 years. Globally, it has invested in 91 innovative biopharma companies and achieved 32 exits through IPO and M&A, including Genmab, PanGenetics (sold to AbbVie), Cellzome (sold to GSK), Micromet (sold to Amgen), Molecular Partners, XO1 (sold to Janssen Pharmaceuticals, Inc.), Minerva Neurosciences, Padlock Therapeutics (sold to Bristol-Myers Squibb), Gadeta (structured transaction with Gilead), Impact BioMedicxines (sold to Celgene) and Adaptive Biotechnologies. Medicxi is also the founding investor of Centessa Pharmaceuticals. Please see https://www.medicxi.com/ for more information.

About RxCapital
RxCapital is the venture capital arm of RxCelerate, a leading international out-sourced drug discovery platform based in Cambridge, UK.  RxCapital invests in early-stage biotechnology companies with transformative capability and, unlike many CROs, there is no requirement for portfolio companies to use RxCelerate services.  RxCapital will invest in any geography, following an asset-centric investment model, deploying up to £1million per investment.  For further information, please contact Nick Tait, Chief Financial Officer of RxCelerate Group: nick@rxcelerate.com.

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NEWS

PRESS RELEASES

Rivus Pharmaceuticals Launches with $35 Million Series A Financing to Develop Novel Treatments for Cardio-Metabolic Diseases

NEWS

PRESS RELEASES

Rivus Pharmaceuticals Launches with $35 Million Series A Financing to Develop Novel Treatments for Cardio-Metabolic Diseases

Advancing a pipeline of first-in-class Controlled Metabolic Accelerators (CMAs) to harness the body’s natural processes to improve cellular metabolism and treat the underlying causes of poor metabolic health and cardiovascular disease

Initial programs to focus on type 2 diabetes, severe hypertriglyceridemia (SHTG), non-alcoholic steatohepatitis (NASH), heart failure with preserved ejection fraction (HFpEF)

CHARLOTTESVILLE, Va., July 20, 2021 /PRNewswire/ — Rivus Pharmaceuticals, Inc., a biopharmaceutical company dedicated to improving cardio-metabolic health, today announced the completion of a $35 million Series A financing. Rivus is advancing a new class of oral, once daily, small molecule therapeutics called Controlled Metabolic Accelerators (CMAs), designed to improve cellular metabolism and treat the underlying cause of highly-prevalent metabolic and cardiovascular diseases. The round was co-led by Longitude Capital and Medicxi and RxCapital also participated.

“More than 40 million people in the U.S. alone are living with cardio-metabolic disorders, conditions that adversely impact a person’s health and quality of life, as well as place significant cost burdens on healthcare systems. While many existing therapeutic options address the downstream effects of metabolic disease, they do little to address the underlying cause – greater consumption of energy than is required by the body, which over time results in inefficient cellular metabolism and the excess accumulation of fat,” said Allen Cunningham, President and CEO, Rivus Pharmaceuticals. “Our CMAs are designed to effectively target the root cause of these diseases by improving cellular metabolism with the potential to halt the progress of, or even reverse, these diseases.”

CMAs provide a new, measured approach to activating mitochondrial uncoupling, a natural process in the body that regulates and dissipates energy. By ferrying protons out of the mitochondrial intermembrane space, CMAs cue the increased oxidation of sugars and fats, while maintaining the same baseline production of adenosine triphosphate (ATP).  Activating this process results in the reduction of accumulated fat and the prevention of additional fat accumulation throughout the body. Rivus is currently conducting a Phase 2a clinical study with its lead CMA therapeutic, HU6. The Series A financing will enable Rivus to advance a pipeline of CMA therapies to treat a range of metabolic conditions including type 2 diabetes, severe hypertriglyceridemia (SHTG), non-alcoholic steatohepatitis (NASH), as well as cardiovascular diseases such as heart failure with preserved ejection fraction (HFpEF).

“We are very encouraged by early clinical results of HU6 and the potential for CMAs to deliver a new and highly-effective approach to improving metabolic health,” said Patrick Enright, Managing Director at Longitude Capital. “There is tremendous global potential for CMAs to fundamentally change the therapeutic landscape across a variety of difficult to manage chronic diseases related to metabolic health.”

“Rivus has recently completed its Phase 1 program for HU6, and the results exceeded our expectations, demonstrating an early positive impact on key metabolic parameters, while being well-tolerated,” said David Grainger, Ph.D., Chief Scientific Advisor at Medicxi. “Phase 2 studies will provide important insights into HU6’s efficacy in specific metabolic and cardiovascular diseases with this very promising new therapy, and we are excited to advance these programs in partnership with Rivus.”

# # #

About Rivus Pharmaceuticals

Rivus Pharmaceuticals, Inc., is dedicated to transforming the treatment of cardio-metabolic disease. Rivus’ first-in-class, small molecule therapy, HU6, is a controlled metabolic accelerator (CMA) that addresses the underlying cause of cardio-metabolic disease by harnessing the body’s natural processes to improve cellular metabolism. Rivus’ therapy presents a tremendous opportunity to empower patients on their journey to better health when facing a broad range of cardio-metabolic conditions, including type 2 diabetes, hypertension, non-alcoholic steatohepatitis (NASH), dyslipidemia and obesity. For more information, please visit www.rivuspharma.com.

About Longitude Capital

Longitude Capital is a leading healthcare venture capital firm that invests in transformative biotechnology, medical technology and health solutions companies seeking to improve clinical outcomes, enhance quality of life, and drive efficiency of healthcare delivery. Founded in 2006, Longitude Capital invests in both privately held and publicly traded companies through a variety of investment approaches. Longitude Capital has offices in Menlo Park, CA, Greenwich, CT, and Boston, MA. For more information, please visit www.longitudecapital.com or LinkedIn.

About Medicxi

Medicxi is an international investment firm with the mission to create and invest in companies across the full healthcare continuum. Medicxi was established by the former Index Ventures life sciences team and invests in both early stage and late stage therapeutics with a product vision that can fulfill a clear unmet medical need. GlaxoSmithKline, Johnson & Johnson Innovation – JJDC, Inc., Novartis and Verily (an Alphabet company) are investors in Medicxi funds.

Medicxi’s team has been investing in life sciences for over 20 years. Globally, it has invested in 91 innovative biopharma companies and achieved 32 exits through IPO and M&A, including Genmab, PanGenetics (sold to AbbVie), Cellzome (sold to GSK), Micromet (sold to Amgen), Molecular Partners, XO1 (sold to Janssen Pharmaceuticals, Inc.), Minerva Neurosciences, Padlock Therapeutics (sold to Bristol-Myers Squibb), Gadeta (structured transaction with Gilead), Impact BioMedicxines (sold to Celgene) and Adaptive Biotechnologies. Medicxi is also the founding investor of Centessa Pharmaceuticals. Please see https://www.medicxi.com/ for more information.

About RxCapital
RxCapital is the venture capital arm of RxCelerate, a leading international out-sourced drug discovery platform based in Cambridge, UK.  RxCapital invests in early-stage biotechnology companies with transformative capability and, unlike many CROs, there is no requirement for portfolio companies to use RxCelerate services.  RxCapital will invest in any geography, following an asset-centric investment model, deploying up to £1million per investment.  For further information, please contact Nick Tait, Chief Financial Officer of RxCelerate Group: nick@rxcelerate.com.

MEDIA CONTACT
info@rivuspharma.com

CONTACT US

For general inquiries please e-mail us at info@rivuspharma.com.